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These alternatively activated macrophages release high levels of pro-metastatic cytokines in the circulation of HCC patients, such as IL-6, IL-1, and TNF- (Ataseven et al., 2006)

ClinicalTrials.gov lists multiple registered studies, including NCT06939088 examining tirzepatide effects on alcohol intake, and NCT06994338 investigating tirzepatide specifically for alcohol use disorder

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